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KMID : 0921620140440020206
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Journal of Bacteriology and Virology
2014 Volume.44 No. 2 p.206 ~ p.207
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Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus
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Park Yeon-Soo
Kim Im-Hyeon
Koh Young-Sang
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Abstract
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Cyclic guanosine monophosphate adenosine monophosphate (cGAMP) synthase (cGAS) detects human immunodeficiency virus (HIV) and produces cGAMP to induce cytokines. Reverse transcribed DNA of HIV is critical for triggering innate immune responses as inhibitor of HIV reverse transcriptase blocked the induction of interferon-β by the virus. Furthermore, knockout of cGAS in human or mouse cell lines abrogated the production of cytokines by HIV infection highlighting the essential role of cGAS in detection of HIV and other retroviruses.
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KEYWORD
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cGAMP synthase (cGAS), Retroviruses, Human immunodeficiency virus, Innate immune system
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